patients and controls, none of
whom showed any signs of already
having cardiovascular disease. The
results of the carotid ultrasound,
however, showed a different story for the SLE patients, with 23
( 36.5%) identified as having carotid plaques, compared with just 2
( 11.1%) of the control group.
Serum HS-c TNT could be detected in more SLE patients than controls (58.7% vs. 33.3%; P = .057),
and the SLE patients who had
detectable levels were nine times
more likely than controls to have a
carotid plaque, Prof. Sacré reported, although the 95% confidence
interval was wide ( 1.55 to 90.07; P
Interestingly, a higher percentage of SLE patients with carotid
plaques than those without had
detectable HS-c TNT (87% vs.
42.5%; P less than .001). Conversely, more patients with detectable
HS-c Tn T than without had a carotid plaque (54.5% vs. 11.5%; P less
In multivariate analyses, only
SLE status and age were signif-
icantly associated with having
carotid plaques, and body mass
index and HS-c Tn T (P = .033) were
presence of carotid plaques in SLE
The research is, of course, preliminary, Prof. Sacré emphasised,
and further investigation is needed.
The study looked at subclinical disease rather than actual CV events,
and that is something to look at
next in a larger cohort of patients
with a longer follow-up period, he
Prof. Sacré disclosed that he had
received support for travel to the
EULAR Congress from Roche Diagnostics France.
The EULAR App
The EULAR App provides information and guidelines on rheumatic and
muskuloskeletal diseases for use by rheumatologists, medical doctors
and health professionals in rheumatology for their everyday work.
EULAR App features include:
· Outcome measures library with calculators
· Imaging library
· Classification material for RMDs
· EULAR pocket primer on rheumatic diseases
- all accessible from any location (online and offline)
Created as part of the EULAR School of Rheumatology.
“Patients with SLE have been known to be at risk for
cardiovascular disease for at least a decade.“